Deletion ofarcDin Streptococcus pneumoniae D39 Impairs Its Capsule and Attenuates Virulence
نویسندگان
چکیده
منابع مشابه
Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39
Pyrimidine nucleotides play an important role in the biosynthesis of activated nucleotide sugars (NDP-sugars). NDP-sugars are the precursors of structural polysaccharides in bacteria, including capsule, which is a major virulence factor of the human pathogen S. pneumoniae. In this work, we identified a spontaneous non-reversible mutant of strain D39 that displayed a non-producing capsule phenot...
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Aspirin or acetylsalicylic acid (ASA) is a medicine used to treat pain, fever, and inflammation. Here, we for the very first time reported the genome-wide transcriptional profiling of aspirin-regulated genes in Streptococcus pneumoniae in the presence of 5 mM aspirin in chemically-defined medium (CDM) using microarray analysis. Our results showed that expression of several genes was differentia...
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Surface capsular polysaccharides play a critical role in protecting several pathogenic microbes against innate host defenses during infection. Little is known about virulence mechanisms of the fish pathogen Streptococcus iniae, though indirect evidence suggests that capsule could represent an important factor. The putative S. iniae capsule operon contains a homologue of the cpsD gene, which is ...
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The polysaccharide capsule is the major virulence factor of Streptococcus pneumoniae (pneumococcus), a major human pathogen. The sequences in the promoter and coding regions of the capsule gene locus undergo extensive variations through the natural transformation-mediated horizontal gene transfer. The sequence variations in the coding region have led to at least 97 capsular serotypes. However, ...
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Amoxicillin subinhibitory concentrations produced 100% survival in passively immunized mice infected with non-amoxicillin-susceptible, poorly or highly encapsulated Streptococcus pneumoniae strains (2, 6), with negligible values of time that serum levels exceeded the MIC. We explored this phenomenon and its modulation by capsular production with levofloxacin against the same serotype 6B Strepto...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2013
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00778-13